Showing posts with label Roche. Show all posts
Showing posts with label Roche. Show all posts

Wednesday, January 20, 2010

Collaboration and IP Rights: But What About Those Transaction Costs?

Surely one of the main themes of the past decade has been the rise of collaboration in R&D and innovation. Whatever one's slogan--"You collectively is smarter than you individually" or "No more 'not invented here'", both popular and and academic literature are replete with accounts of the challenges and rewards of collaboration as opposed to go-it-alone development. Aided by the universal reach of online communications and infrastructure, as well as the global movement of ideas, resources and manpower, collaboration is championed on both substantial and process grounds.

Against the almost epiphanic adulation in favour of such collaboration, however, there remains a dirty little secret: it is often times devilishly difficult to find a workable arrangement for the allocation of IP rights in such circumstances. Just one example --the mind-numbing exercise of distinguishing between "Background IP" and "Foreground IP" has become a common nightmarish staple in fashioning collaboration agreements. More generally, the challenge of establishing a workable framework for determining ownership of IP rights, both individually and jointly, is daunting under the best of circumstances and is a potential show-stopper in less favourable situations.

It is against this backdrop that I recently read an account in the December 7, 2009 issue of Business Week ("Can Roche Leave Genentech Alone?") of the efforts by Roche to implement its acquisition of the 44% of Genentech that Roche did not previously own (in early 2009, we discussed the Roche-Genentech acquisition on this blog here.) One comment in the piece particularly caught my attention: the observation that the acquistion will finally allow the two companies to work together in an effective manner on what is termed "personalized medicine", with the goal of developing "diagnostics", namely the development of the technologies used by doctors to ascertain better which drugs work with which patients.

What exactly was the reason that the development of these "diagnostics" did not take place before the acquisition, even though Roche already owned over 50% of Genentech? According to the article, the reason centred on the issue of IP rights. "When they were separate, Genentech and Roche rarely tried to codevelop diagnostics, because it took too long to work out patent rights and other legal logistics. 'Now there's no intellectual property discussion, there's no negotiation -- we're the same! ... You wouldn't believe how much easier it is.' "

At first glance, this observation seems to be a testimony to the frictions created by transaction costs with respect to IP rights in collaboration arrangements. In particular, as noted by Wikipedia, "Bargaining costs are the costs required to come to an acceptable agreement with the other party to the transaction, drawing up an appropriate contract and so on." Here, the argument seems to be that the bargaining costs in arranging for the disposition of IP rights in a collaborative relationship were, at least with respect to the Roche-Genentech relationship before the full acquisition, prohibitive. The result was that wide collaboration regarding diagnostics did not appear to take place.

There is something disturbing in all of this. Can it be that the transaction costs in bargaining the disposition of IP rights in a collaborative arrangement between two separate parties are so daunting that the only feasible solution is for the two parties to merge, thereby eliminating the friction in the contractual bargaining? Think about it: If the answer is "yes", then it calls into question the ability of lawyers to fashion arrangements for collaboration, other than an outright acquisition of one party by the other (was not Oliver Williamson the co-recipient of the 2090 Nobel Prize in Economics for studying this kind of thing?)

Surely (at least I would like to think "surely"), however, lawyers and their clients engage all the time in reaching an arrangement for the disposition of IP rights in collaboration agreements in situations other than an outright acquisition. Sometimes the negotiations over which party will own what IP rights in a collaboration are less rocky, sometimes more so. As the report on Roche and Genentech indicate, sometimes the collaboration dies a legal stillbirth.


Given this range of possibilities, it seems to me that the better question is how we should understand the parameters for effectively bargaining this disposition of rights in the more typical collaboration arrangement, when acquisition of one party by the other is not on the table. Against this background, we can then perhaps better understand what were the particular factors in the pre-acquisition relationship between Roche and Genentech that seem to have paralyzed any effective bargaining of IP rights between them, at least with respect to diagnostics. There may be an interesting MBA case study here to explore these questions. Any takers?

Saturday, March 14, 2009

Roche and Genentech: The Knot Is Nearly Tied

Following my report on Thursday evening regarding the acquisition by Merck of Schering-Plough, let us consider briefly the announcement made on Thursday that Roche has succeeded in convincing the board of Genentech to purchase the remaining 44% of the iconic U.S. biotech company that Roche did not previously own. The amount of the offer is $46.8 billion dollars. The tender offer will be in effect until March 25th and is based on $95 per share (in case any of our readers happens to own Genentech shares). The offer is 9.8% above the lowest offer that Roche made for Genentech in a process that began last summer. Roche has held a stake in Genetech for nearly 20 years.

First, some facts: Roche, located in Switzerland, is the world's largest manufacturer of cancer drugs, while Genentech is ... Genentech, a pioneer in the biotech world, and located a continent and culture away, in South San Francisco. The key to the consummation of the offer by Roche and acceptance by Genentech seems to be the Avastin cancer drug. As reported by Bloomberg.com,
"Avastin is approved to treat colon, lung and breast tumors and is being tested in more than 400 clinical trials involving 40,000 patients worldwide. The treatment may become the best-selling medicine in the world within six years, London-based consultant EvaluatePharma said in August."
As an indication of its potential, consider that Avastin garnered $4.52 billion in sales for Roche in 2008. By consummating the deal, Roche will reportedly be able to pare costs (what merger does not claim this?), enhance its income from cancer-related drugs at a time when income for the broader drug business slows, and guarantee that Roche will have access to Genetech's labs after 2015, when a current accord between the two companies comes to an end.

It is this last point that troubles me a bit--let's hope for Roche's sake that the Gententech labs in 2015 will be blessed with same developmental elan that has seems to have marked it throughout its tenure as an independent company. Without having any direct contact with either a Roche or Genetech facility, I can still say from experience with other companies in these respective locations that it the corporate cultures of a Swiss Big Pharma titan and a legendary biotech Silicon company are likely to be quite different from each other.

It will be a challenging test for the two companies to mesh their cultures in a way by which the arrangement is a win-win situation down the line, after Avastin passes from the scene and/or it (other Gententech cancer products )encounters stiffer competition from other cancer drugs. The real test is not today, or even five years from now, but 2o years hence (the time during which Roche has had in interest in Genentech), to measure the ultimate success of the venture.

Genentech - ever upward and onward?

And that is the ultimate rub. The short-term motivation for this spate of 2009 acquisitions in Big Pharma seems to be a confluence of lots of cash ($100 billion according to Bloomberg), and the need to replace $84 billion in sales from products whose patent protection is set to expire (also according to Bloomberg). The ultimate test will be new products, which means continued successful R&D. Whether these acquisitions is the best way to accomplish that goal (which is in truth a never-ending moving target) awaits the long-term verdict of the markets.

Roche and Genentech: one view of the long road?